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A. Crystal structure of LINGO-1 tetrameric extracellular domain shows four LINGO-1 oligomers (depicted in yellow, green red and magenta) in a ring like structure on cell surface (adopted from Mosyak et al. [13]).
B. Role of LINGO-1 is responsible for neuronal and oligodendrocytes growth and regeneration pathways.
C. Outline of LINGO-1 expression locations in the CNS and in EWS tumours.
