Table 2. Independent factors associated with early and late mortality in the ALD cohort (abbreviated).
See eTable 1 for full table.
| Characteristic | Characteristic | 5-year death (%) | Early 0-30d death (%) | Late 31d-5y death (%) | Early Multivariable regression HR (95%CI) p-value |
Late Multivariable regression HR (95%CI) p-value |
|---|---|---|---|---|---|---|
| n | 2463 | 2463 | 1106 | |||
| Age (years) | per 10 year increase | - | - | - | 1.24 (1.19, 1.29) <0.001 | 1.33 (1.19, 1.50) <0.001 |
| Sex | Male | 83.3% | 54.0% | 57.5% | 1 (Reference) | 1 (Reference) |
| Female | 81.9% | 56.7% | 49.2% | 1.02 (0.92, 1.13) 0.652 | 0.73 (0.58, 0.93) 0.010 | |
| Socioeconomic status quintile | 1 Least deprived | 85.0% | 56.0% | 59.5% | 1 (Reference) | 1 (Reference) |
| 2 | 80.2% | 52.5% | 52.0% | 1.01 (0.64, 1.57) 0.978 | 0.75 (0.61, 0.91) 0.004 | |
| 3 | 84.1% | 49.5% | 63.8% | 1.03 (0.67, 1.58) 0.885 | 1.08 (0.80, 1.46) 0.622 | |
| 4 | 84.5% | 58.2% | 55.3% | 1.19 (0.77, 1.85) 0.438 | 0.89 (0.55, 1.45) 0.642 | |
| 5 Most deprived | 81.7% | 55.7% | 50.2% | 1.11 (0.75, 1.63) 0.601 | 0.78 (0.55, 1.09) 0.140 | |
| Comorbidity count | 0 | 82.4% | 55.0% | 53.9% | 1 (Reference) | 1 (Reference) |
| 1 | 83.6% | 55.3% | 55.3% | 1.13 (0.99, 1.30) 0.063 | 0.78 (0.61, 0.99) 0.043 | |
| 2 | 86.1% | 55.1% | 63.3% | 1.18 (0.78, 1.79) 0.432 | 1.07 (0.69, 1.68) 0.758 | |
| 3+ | 87.3% | 48.4% | 72.0% | 1.12 (0.72, 1.75) 0.621 | 1.04 (0.63, 1.73) 0.871 | |
| Previous year hospital admissions | 0 | 82.4% | 58.9% | 47.7% | 1 (Reference) | 1 (Reference) |
| 1 | 81.5% | 54.4% | 52.0% | 0.96 (0.86, 1.09) 0.550 | 1.25 (0.91, 1.71) 0.172 | |
| 2 | 84.7% | 54.6% | 61.1% | 0.97 (0.80, 1.18) 0.775 | 1.69 (1.03, 2.79) 0.039 | |
| 3 | 84.5% | 48.9% | 65.3% | 0.93 (0.77, 1.12) 0.448 | 2.19 (1.34, 3.55) 0.002 | |
| 4+ | 83.8% | 47.2% | 64.5% | 0.89 (0.72, 1.10) 0.283 | 1.76 (1.12, 2.77) 0.015 | |
| Admission source | See eTable 2 | |||||
| ICU admission diagnosis | Variceal bleed | 78.7% | 42.4% | 57.8% | 1.89 (1.14, 3.15) 0.014 | 1 (Reference) |
| Pneumonia | 83.0% | 54.1% | 56.5% | 1.67 (1.05, 2.66) 0.031 | 1.08 (0.64, 1.84) 0.767 | |
| Septic shock | 88.0% | 67.6% | 54.1% | 1.90 (1.04, 3.49) 0.037 | 1.05 (0.50, 2.17) 0.905 | |
| Liver failure | 89.7% | 73.0% | 53.5% | 2.16 (1.17, 3.99) 0.013 | 1.01 (0.72, 1.41) 0.960 | |
| Post-cardiac arrest | 93.4% | 80.9% | 57.6% | 3.23 (1.93, 5.40) <0.001 | 1.04 (0.65, 1.67) 0.877 | |
| Seizures | 70.9% | 26.0% | 57.4% | 1 (Reference) | 1.80 (1.05, 3.10) 0.034 | |
| Other | 71.4% | 49.2% | 51.8% | 1.91 (1.32, 2.77) 0.001 | 1.04 (0.72, 1.51) 0.819 | |
| Acute Physiology Score | per 10 point increase | - | - | - | 1.83 (1.66, 2.02) <0.001 | 0.89 (0.74, 1.07) 0.205 |
| Number of organs supported at admission | 0 | 71.4% | 33.2% | 52.5% | 1 (Reference) | 1 (Reference) |
| 1 | 81.1% | 48.0% | 58.0% | 1.39 (1.18, 1.64) <0.001 | 1.36 (1.06, 1.74) 0.016 | |
| 2 | 87.9% | 68.0% | 52.6% | 1.94 (1.69, 2.23) <0.001 | 1.23 (1.06, 1.42) 0.007 | |
| 3 | 89.8% | 79.0% | 37.0% | 2.12 (1.50, 3.01) <0.001 | 0.80 (0.55, 1.16) 0.237 | |
| Liver SOFA score | 0 | 70.4% | 36.7% | 46.1% | 1 (Reference) | 1 (Reference) |
| 1 | 78.2% | 46.1% | 53.2% | 1.20 (0.98, 1.46) 0.070 | 1.20 (0.82, 1.75) 0.355 | |
| 2 | 83.4% | 55.6% | 55.6% | 1.79 (1.40, 2.30) <0.001 | 1.42 (1.11, 1.81) 0.006 | |
| 3 | 88.7% | 65.5% | 61.5% | 2.19 (1.76, 2.72) <0.001 | 1.98 (1.53, 2.57) <0.001 | |
| 4 | 93.4% | 77.6% | 63.4% | 2.92 (2.29, 3.73) <0.001 | 2.02 (1.36, 2.99) <0.001 | |
| Missing | 85.9% | 57.7% | 60.7% | 2.09 (1.54, 2.84) <0.001 | 1.66 (1.32, 2.10) <0.001 |
Kaplan-Meier estimator presented for % death. Multivariable Cox models are stratified by health board of residence. HR, hazard ratio; ICU, intensive care unit; SOFA, Sequential Organ Failure Assessment.