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. Author manuscript; available in PMC: 2019 Aug 8.
Published in final edited form as: Neurodegener Dis. 2018 Aug 8;18(4):173–190. doi: 10.1159/000488780

Table 4:

Results of posterior estimates of parameters and corresponding 95% credible interval for model with 8 outcomes from the Parkinson’s Progression Markers Initiative (PPMI).

Parameter Posteri or Mean 95% Credible Interval Parameter Posteri or Mean 95% Credible Interval
CSF Alpha-synuclein SCOPA
Intercept 0.8976 (0.4341,1.3793) Intercept −2.3726 (−2.7089,−2.0074)
Age −0.0123 (−0.0200,−0.0050) Age 0.0336 (0.0279,0.0387)
Female −0.1160 (−0.2745,0.0401) Female 0.5104 (0.3944,0.6296)
Latent time, γ1 0.0274 (0.0190,0.0363) Latent time, γ5 0.0406 (0.0338,0.0486)
Error Variance, σ1 0.4288 (0.4023,0.4552) Error Variance, σ5 0.4683 (0.4559,0.4819)
PIGD Tremor
Intercept −1.9367 (−2.6663,−1.1232) Intercept 0.3527 (−0.3759,1.1549)
Age 0.0114 (−5e-04,0.0226) Age −0.0174 (−0.0295,−0.0064)
Female 0.0866 (−0.1579,0.3315) Female −0.1660 (−0.3967,0.0813)
Latent time, γ2 0.1415 (0.1225,0.1621) Latent time, γ6 0.1236 (0.1084,0.1404)
Error Variance, σ2 1.1573 (1.1347,1.1788) Error Variance, σ6 0.8108 (0.7962,0.827)
REM Sleep UPDRS Total
Intercept 0.2397 (−0.1764,0.6504) Intercept −0.2535 (−0.6679,0.176)
Age −0.0053 (−0.0118,8e-04) Age 0.0059 (−8e-04,0.0123)
Female −0.1052 (−0.2437,0.0494) Female −0.0364 (−0.1758,0.0979)
Latent time, γ3 0.0446 (0.0364,0.053) Latent time, γ7 0.0880 (0.0769,0.0999)
Error Variance, σ3 0.5806 (0.5646,0.5968) Error Variance, σ7 0.3494 (0.343,0.3559)
SBR Striatum UPSIT
Intercept −0.8843 (−1.2600,−0.5038) Intercept −1.2072 (−1.6254,−0.7688)
Age 0.0157 (0.0098,0.0215) Age 0.0206 (0.0138,0.0275)
Female −0.0677 (−0.2017,0.0604) Female −0.2175 (−0.348,−0.0731)
Latent time, γ4 0.0599 (0.0502,0.0697) Latent time, γ8 0.0511 (0.0418,0.0615)
Error Variance, σ4 0.2118 (0.2002,0.2237) Error Variance, σ8 0.3688 (0.0688,0.6602)
Heterogeneous parameters Model criteria
τ1 5.1320 (4.4178,5.8806) WAIC 61054.80
τ2 −0.0071 (−.018,0.0033) LOOIC 62158.01
τ3 −0.0184 (−0.2247,0.1919)