FIG. 1.

Increases in carotid artery intima-media thickness (CIMT) of Mayo KEEPS participants from values at the time of randomization to treatment (year 0) through the 4 years of the trial and at 3 years after cessation of treatment. Each point represents a measurement per individual per visit, with repeated measurements over all study visits. Curves depict time trends based on the LOWESS method, which estimate, by nonparametric analysis, the relationship between time and CIMT by group without assuming linearity. CEE, conjugated equine estrogen; E₂, 17β-estradiol.