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. 2019 Jan 7;216(1):176–194. doi: 10.1084/jem.20181170

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© 2018 Lee et al.

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Figure 9. — Proposed mechanism for the metastatic tropism of ovarian cancer for the omentum. Early-stage ovarian tumors secrete factors that stimulate influx of neutrophils into the premetastatic omental niche and induce these neutrophils to form NETs. Cancer cells that are shed by tumors into the circulating peritoneal fluid become trapped by NETs and then form implants on the omentum.