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. 2019 Jan 7;218(1):125–133. doi: 10.1083/jcb.201804207

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© 2018 Noblett et al.

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Figure 2. — dip-2 mutants display an age-dependent increase in neuronal morphology defects. (A) Representative images of mechanosensory neuron morphology in WT and dip-2 mutants at D1 and D5. Arrows indicate ectopic neurites. Bar, 20 µm. (B) ALM neurons in dip-2 mutants display a cumulative increase in ectopic neurites with increasing age compared with a lesser increase in WT animals. Some ectopic ALM neurites in dip-2 mutants show additional age-dependent secondary branching (arrowhead in A). (C and D) PLM, AVM, and PVM also display age-dependent increases in ectopic neurites. Error bars indicate SD for data collected from three independent counts of 40–75 ALM or PLM and 15–40 AVM or PVM neurons. Significance compared with WT at each life stage using one-way ANOVA with Tukey post hoc test. *, P < 0.05; **, P < 0.01; ***, P < 0.001.