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. 2019 Jan 7;218(1):55–69. doi: 10.1083/jcb.201808028

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© 2018 Di Carlo et al.

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Figure 1. — Mammalian PRC1/2 compositional complexity. (A) PcG proteins RING1A/B and PCGF1−6 compose a core around which accessory subunits associate. cPRC1 incorporates one PHC and one CBX protein. Noncanonical PRC1 (ncPRC1) complexes incorporate RYBP/YAF2 along with specific sets of additional proteins. (B) PRC2 shares a similar organization, with a tetrameric core composed of EZH1/2, SUZ12, EED, and RBBP4/7. Association with PCL proteins defines a PRC2.1 subtype that can associate with either EPOP or PALI1/2 (PRC2.1a/b). Conversely, association with AEBP2 and JARID2 defines a PRC2.2 subtype.