| Core PRC1 |
RING1A/B |
H2A monoubiquitylation and nucleosome binding |
| PCGF1−6 |
Stimulation of enzymatic activity |
| PRC1.2, 4 |
CBX2,4,6−8 |
H3K9/K27me3 binding |
| PHC1−3 |
Oligomerization and chromatin compaction |
| SCMH1/L2 |
Histone methyl–lysine binding and RNA binding |
| PRC1.1, 3, 5, 6 |
RYBP/YAF2 |
DNA binding (unspecific) and interaction with YY1 |
| PRC1.1 |
BCOR/BCORL1 |
Scaffold |
| KDM2B |
H3K36 demethylation and DNA binding (unmethylated CpG islands) |
| SKP1 |
Ubiquitin ligase and interaction with CUL1 |
| USP7 |
Stimulation of enzymatic activity |
| PRC1.3, 5 |
DCAF7 |
Scaffold |
| CK2 |
Inhibition of enzymatic activity |
| AUTS2/FBRS/FBSL |
Transcription activation |
| PRC1.6 |
WDR5 |
Scaffold |
| L3MBTL2 |
Histone methyl–lysine binding and chromatin compaction |
| HP1γ/CBX3 |
H3K9me3 binding |
| JARID1C |
H3K4me2/3 demethylase |
| G9a |
H3K9 methyltransferase |
| HDAC1/2 |
Histone deacetylase |
| DP-1 |
DNA binding (E2F recognition site) |
| E2F6 |
DNA binding (E2F recognition site) |
| MAX |
DNA binding (E-boxes) |
| MGA |
DNA binding (E-boxes) |
| Core PRC2 |
EZH1/2 |
H3K27 methyltransferase |
| SUZ12 |
DNA/RNA binding |
| EED |
H3K27me3 binding |
| RBBP4/7 |
Histones binding |
| PRC2.1 |
PCL1/PHF1 |
H3K36me2/3 binding, DNA binding (unspecific), and stimulation of enzymatic activity |
| PCL2/MTF2 |
H3K36me2/3 binding and DNA binding (unmethylated CpG islands) |
| PCL3/PHF19 |
H3K36me2/3 binding |
| EPOP |
Inhibition of enzymatic activity and interaction with Elongin B and C |
| PALI1/2 |
Stimulation of enzymatic activity |
| PRC2.2 |
JARID2 |
DNA/RNA binding, H2Aub binding, and stimulation of enzymatic activity |
| AEBP2 |
DNA binding, H2Aub binding, and stimulation of enzymatic activity |
