Table 4. Effect of increased water intake on renal function.
| Lewis | LPK | |||
|---|---|---|---|---|
| Variables | NWI | HWI | NWI | HWI |
| Week 10 | n = 8 | n = 8 | n = 17 | n = 16 |
| Serum creatinine (μmol/L) | 26±6 | 26±4 | 47±23 | 49±13 |
| CrCl/BW (ml/min/g) | 6.4±1.9 | 7.4±1.7 | 2.8±0.9* | 3.0±1.1 |
| Urine PCR (mg/mmol Cr) | 39.8±29.9 | 116.8±88.9 | 297.7±499.0 | 334.2±261.4 |
| Week 16 | n = 8 | n = 8 | n = 17 | n = 16 |
| Serum creatinine (μmol/L) | 33±10 | 33±9 | 93±42* | 71±31 |
| CrCl/BW (ml/min/g) | 5.7±1.4 | 5.4±1.6 | 1.7±1.4* | 2.0±1.4 |
| Urine PCR (mg/mmol Cr) | 23.1±15.3 | 149.4±101.1 | 1171.2±1387.8‡ | 346.6±370.4§ |
Urine PCR; urine protein creatinine ratio; CrCl/BW, creatinine clearance corrected for body weight. Values represented as mean ± SD.
*p<0.001 versus age-matched NWI Lewis rat
†p<0.001 versus age-matched LPK NWI
‡p<0.05 versus age-matched NWI Lewis rat
§p<0.05 versus age-matched NWI LPK rat