Table 5. Effect of increased water intake on cardiac enlargement.

	Males				Females
	Lewis		LPK		Lewis		LPK
Variables	NWI	HWI	NWI	HWI	NWI	HWI	NWI	HWI
Week 10	n = 4	n = 4	n = 7	n = 8	n = 3	n = 4	n = 9	n = 8
Cardiac weight (g)	0.77±0.06	0.68±0.04	1.09±0.07*	1.14±0.08	0.48±0.08	0.51±0.03	0.86±0.07*	0.84±0.08
HW:BW (%)	0.31±0.03	0.3±0.001	0.55±0.07*	0.53±0.06	0.34±.03	0.35±0.02	0.57±0.06*	0.52±0.05
Week 16	n = 4	n = 4	n = 8	n = 10	n = 5	n = 4	n = 9	n = 6
Cardiac weight (g)	0.85±0.13	0.88±0.05	1.34±0.16*	1.34±0.12	0.64±0.07	0.57±0.13	0.97±0.13*	1.04±0.09
HW:BW (%)	0.28±0.02	0.28±0.02	0.57±0.10*	0.45±0.06§	0.34±0.02	0.30± 0.07	0.53±0.06*	0.57±0.06

HW:BW%: heart weight to body weight ratio expressed as a percentage. mean ± SD.

*p<0.001 versus age-matched NWI Lewis rat

†p<0.001 versus age-matched LPK NWI

‡p<0.05 versus age-matched NWI Lewis rat

§p<0.05 versus age-matched NWI LPK rat.