Table 5. miRNAs with changes related to TBI likelihood.
miRNA | TBI | Fluid | Interaction | Change Saliva | Change Serum | Top Human Tissues | Human CSF |
---|---|---|---|---|---|---|---|
miR-7-1-3p | 0.147 | 0.853 | 0.417 | ↓ | - | Fetal CNS, nose, pharynx, lymphoid, adipose | |
miR-10a-5p | 0.136 | 0.131 | 0.417 | ↓ | ↑ | Kidney, stomach, uterus, liver, lung | ++++ |
miR-10b-5p | 0.119 | 0.234 | 0.739 | ↑ | ↑ | Uterus, prostate, bladder, breast, head | ++++ |
miR-20a-5p | 0.136 | 0.987 | 0.396 | ↑ | - | Kidney, lymphoid, uterus | + |
miR-30b-5p | 0.136 | 0.408 | 0.723 | ↑ | ↑ | Breast, nose, testes, heart | ++ |
miR-92a-3p | 0.119 | 0.987 | 0.594 | ↓ | ↓ | Kidney, fetal CNS, tonsil, adult CNS, lymphocyte | ++++ |
miR-122-5p | 0.119 | 0.024 | 0.162 | - | ↑ | Germ line cells, liver, kidney | +++ |
miR-128-3p | 0.147 | 0.850 | 0.803 | ↓ | ↑ | CNS, lung, fetal lung, lymphoid | ++ |
miR-155-5p | 0.147 | 0.589 | 0.806 | - | ↑ | Lymphoid, tonsil, umbilical cord | ++ |
miR-455-5p | 0.136 | 0.803 | 0.896 | ↓ | ↓ | Skin, keratinocytes, uterus, heart, liver, cerebellum | + |
miR-1307-3p | 0.147 | 0.720 | 0.760 | ↓ | ↑ | Pharynx, kidney, liver thyroid, head | ++ |
miR-3146 | 0.119 | 0.649 | 0.844 | ↓ | - | Lymphocytes, uterus, keratinocytes, kidney, tonsil | + |
miR-3678-3p | 0.147 | 0.922 | 0.821 | ↓ | ↓ | Lymphocyte, Tonsil | |
miR-376a-5p | 0.021 | 0.535 | 0.749 | ↓ | - | Skin, placenta, heart, CNS, testes | + |
miR-4637 | 0.136 | 0.689 | 0.516 | - | ↑ | Uterus, lymphoid, tonsil, keratinocytes, liver, CNS | |
miR-4649-3p | 0.119 | 0.091 | 0.139 | ↓ | - | Nose, uterus, foreskin fibroblasts | |
miR-4693-5p | 0.119 | 0.320 | 0.812 | - | ↑ | ‘- | |
miR-4766-5p | 0.147 | 0.015 | 0.139 | ↓ | - | Lymphoid, uterus, kidney, liver | + |
miR-5694 | 0.147 | 0.649 | 0.665 | ↓ | ↓ | Uterus, breast, brain, spleen, thymus | + |
miR-6770-5p | 0.136 | 0.235 | 0.825 | ↓ | - | ‘- | ++ |
miR-6809-3p | 0.119 | 0.269 | 0.668 | ↓ | ↓ | ‘- | + |
Note: miRNAs in bold are displayed in subsequent figures. Top expressing tissues referenced from miRGator expression atlas of normal organs (http://mirgator.kobic.re.kr). Human cerebrospinal fluid (CSF) data referenced from Hicks and colleagues [12] based on reads per million (RPM) in control or TBI subject CSF according to log10 expression levels: + (>10 RPM), ++ (>100 RPM), +++ (>1,000 RPM), ++++ (>10,000 RPM).