Table 7. Biological pathways overrepresented by target genes of HTH-related miRNAs.
| KEGG pathway | FDR | Genes | miRNAs | 10a-5p | 10b-5p | 122-5p | 128-3p | 155-5p | 20a-5p | 30b-5p | 3146 | 3678-3p | 376a-5p | 455-5p | 4637 | 4649-3p | 4693-5p | 4766-5p | 5694 | 6770-5p | 6809-3p | 7-1-3p | 92a-3p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Proteoglycans in cancer | 1.1E-06 | 102 | 20 | -/+ | +/+ | /+ | -/+ | /+ | +/ | +/+ | -/ | -/- | -/ | -/- | /+ | -/ | /+ | -/ | -/- | -/ | -/- | -/ | -/- |
| Mucin type O-Glycan biosynthesis | 2.7E-05 | 16 | 12 | -/+ | +/+ | /+ | -/+ | /+ | +/ | +/+ | -/ | n/a | n/a | n/a | n/a | -/ | n/a | n/a | n/a | -/ | -/- | -/ | n/a |
| TGF-beta signaling pathway | 2.7E-05 | 46 | 20 | -/+ | +/+ | /+ | -/+ | /+ | +/ | +/+ | -/ | -/- | -/ | -/- | /+ | -/ | /+ | -/ | -/- | -/ | -/- | -/ | -/- |
| FoxO signaling pathway | 3.2E-05 | 75 | 17 | -/+ | +/+ | /+ | -/+ | /+ | +/ | +/+ | n/a | -/- | -/ | n/a | n/a | -/ | /+ | -/ | -/- | -/ | -/- | -/ | -/- |
| Ubiquitin mediated proteolysis | 3.2E-05 | 80 | 19 | -/+ | +/+ | /+ | -/+ | /+ | +/ | +/+ | -/ | -/- | n/a | -/- | /+ | -/ | /+ | -/ | -/- | -/ | -/- | -/ | -/- |
| Hippo signaling pathway | 3.3E-05 | 76 | 16 | -/+ | +/+ | n/a | -/+ | /+ | +/ | +/+ | -/ | -/- | -/ | n/a | n/a | -/ | /+ | -/ | n/a | -/ | -/- | -/ | -/- |
| Axon guidance | 5.9E-05 | 70 | 17 | -/+ | +/+ | /+ | -/+ | /+ | +/ | +/+ | n/a | -/- | -/ | n/a | n/a | -/ | /+ | -/ | -/- | -/ | -/- | -/ | -/- |
| Ras signaling pathway | 0.0002 | 111 | 19 | -/+ | +/+ | /+ | -/+ | /+ | +/ | +/+ | -/ | -/- | -/ | n/a | /+ | -/ | /+ | -/ | -/- | -/ | -/- | -/ | -/- |
| AMPK signaling pathway | 0.0002 | 67 | 20 | -/+ | +/+ | /+ | -/+ | /+ | +/ | +/+ | -/ | -/- | -/ | -/- | /+ | -/ | /+ | -/ | -/- | -/ | -/- | -/ | -/- |
| Glutamatergic synapse | 0.0003 | 61 | 17 | -/+ | +/+ | /+ | -/+ | /+ | +/ | +/+ | -/ | -/- | -/ | n/a | n/a | -/ | /+ | -/ | n/a | -/ | -/- | -/ | -/- |
+/- symbols indicate direction of change for saliva (left) and serum (right) samples in Very Likely TBI vs Low probability TBI groups, respectively (minimum change +/- 0.1). Absence of one symbol indicates no change. n/a indicates a miRNA not in that group.