Table 3.

NCI Braak V cases compared with age-, gender-, education-, and APOE genotype-matched AD Braak V cases

	NCI (n = 5)	AD (n = 5)	p-value
Midfrontal Cortex NPs	8 [5–18]	32 [14–48]	0.03
Midtemporal Cortex NPs	15 [5–29]	28 [8–93]	0.17
Inferior Parietal Cortex NPs	8 [4–19]	23 [8–57]	0.09
Entorhinal Cortex NPs	8 [1–20]	15 [3–43]	0.53
Hippocampal CA1 NPs	11 [4–23]	12 [6–37]	0.75
Midfrontal Cortex DPs	11 [5–35]	22 [6–68]	0.17
Midtemporal Cortex DPs	20 [6–21]	31 [2–48]	0.35
Inferior Parietal Cortex DPs	8 [4–16]	21 [6–61]	0.17
Entorhinal Cortex DPs	13 [4–24]	3 [0–17]	0.11
Hippocampal CA1 DPs	1 [0–50]	6 [0–11]	0.46
Midfrontal Cortex NFTs	0 [0–1]	1 [0–10]	0.42
Midtemporal Cortex NFTs	5 [4–43]	9 [6–18]	0.46
Inferior Parietal Cortex NFTs	1 [0–2]	4 [0–20]	0.16
Entorhinal Cortex NFTs	32 [3–66]	36 [18–53]	0.92
Hippocampal CA1 NFTs	20 [0–29]	30 [7–47]	0.14

NPs, neuritic plaques; DPs, diffuse plaques; NFTs, neurofibrillary tangles; median [range]; group differences were analyzed using the Mann-Whitney test; significance level is p ≤ 0.005 after correcting for multiple comparisons.