Fig. 1.

Generation of oxylipins derived from n-6 LA and AA, and n-3 ALA, EPA, and DHA via lipoxygenase (LOX), cyclooxygenase (COX), cytochrome P450 (CYP), and non-enzymatic oxidation. Colors depict the precursor pathway metabolite families: LA (green), AA (red), ALA (tan), EPA (purple), DHA (dark red), LA, linoleic acid; AA, arachidonic acid; ALA, α-linolenic acid, EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; EpODE, epoxy-octadecadienoic acid; HODE, hydroxy-octadecadienoic acid; oxoODE, keto-octadecadienoic acid; EPOME, epoxy-octadecenoic acid; DiHOME, dihydroxy-octadecenoic acid, TriHOME, trihydroxy-octadecenoic acid; H-E-LA, hydroxyepoxy-octadecenoic acid; K-E-LA, keto-epoxy-octadecenoic acid; HPOTrE, hydroperoxy-octadecatrienoic acid, HOTrE, hydroxyoctadecatrienoic acid; PGG, hydroperoxide-endoperoxide prostaglandin; PG, prostaglandin; TX, thromboxane; LT, leukotriene; LX, lipoxin; HpETE, hydroperoxyeicosatetraenoic acids; HETE, hydroxypentaenoic acid; oxoETE, keto-eicosatetraenoic acid; EET, epoxyeicosatrienoic acids; HpEPE, hydroperoxyeicosapentaenoic acids; HEPE, hydroxyeicosapentaenoic acid; EEQ, epoxy eicosatetraenoic acid; HpDHA, hydroperoxy-docosahexaenoic acid, HDHA, hydroxyl-docosahexaenoic acid; EDP, epoxy docosapentaenoic acid; DiHDHA, hydroxydocosahexaenoic acid; PDX, 10S,17S-DiHDHA; PD/NPD, protectin; Rv, resolving