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. Author manuscript; available in PMC: 2019 Jan 2.
Published in final edited form as: Chem Commun (Camb). 2018 Dec 13;54(100):14089–14092. doi: 10.1039/c8cc08533a

Fig. 5.

Fig. 5

(a) 1H NMR analysis of the reaction of N6-Ms-SIN 4a (2 mM) and DIBAC-COOH 5 (2.2 mM) in DMSO-d6/D2O (9 : 1 v/v). δ = 3.82 ppm is H2O. aOnly one regioisomer is depicted. (b) Measured rate constants (k2, in M−1 s−1) for reactions between 4a–c and 5 at 22 °C. (c) IC50 values against human COX-2. b 95% confidence interval (n = 2) is given in parentheses.