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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: J Hepatol. 2018 Jun 8;69(5):1136–1144. doi: 10.1016/j.jhep.2018.05.038

Fig. 4. Genetic depletion of NLRP3 suppresses cholestasis, portal inflammation and bile duct obstruction.

Fig. 4.

Serum total bilirubin (A and D) and ALT levels (B and E) in Nlrp3−/−, Casp1−/− and WT mice; N=3–7 per group/time point. *P < 0.05, **P < 0.01, ***P < 0.001. (C and F) Representative panels of H&E staining of liver and EHBD 11 days after RRV injection in Nlrp3−/− (N=17), with intact epithelium and patent lumen (C), while Casp1−/− mice (N=14) have obstructed lumen and expanded portal inflammation (F). Arrows denote portal tracts. * denotes duct lumen; magnification × 200.