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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: CNS Drugs. 2018 Nov;32(11):981–996. doi: 10.1007/s40263-018-0572-y

Table 1:

Endogenous opioid peptides and their high affinity receptors

PRECURSOR PEPTIDES RECEPTOR ACIVITY
POMC β-endorphin delta, mu
PENK leucine-enkephalin delta, mu
methionine -enkephalin
PDYN dynorphins A and B, and neoendorphins delta, kappa, mu
PNOC nociceptin NOP

POMC, proopiomelanocortin; PENK, preproenkephalin; PDYN, preprodynorphin; PNOC, prepronociception; NOP, nociception opioid peptide receptor.