Table 5.
Multivariable linear regression models for association of preconceptional cardiovascular health and pregnancy outcomes in SLE in the Hopkins Lupus Pregnancy Cohort (n=309 pregnancies).
| Cardiovascular Health | Gestational Age | Birthweight for Gestational Age Z-Score | ||
|---|---|---|---|---|
| β (95% CI) | Adjusted β (95% CI) | β (95% CI) | Adjusted β (95% CI) | |
| Body Mass Index* | ||||
| Ideal Health (low/normal BMI; n=163) | Ref | Ref | Ref | Ref |
| Intermediate Health (overweight; n=69) | 0.19 (−0.65, 1.01) | 0.14 (−0.63, 0.93)§ | 0.29 (0.03, 0.56) | 0.32 (0.06, 0.59)§ |
| Poor Health (obese; n=59) | 0.75 (−0.21, 1.71) | 0.70 (−0.24, 1.65)§ | 0.08 (−0.24, 0.41) | 0.14 (−0.18, 0.45)§ |
| Total Cholesterol† | ||||
| Ideal Health (n=235) | Ref | Ref | Ref | Ref |
| Intermediate/Poor Health (n=40) | −0.53 (−1.46, 0.40) | −0.43 (−1.28, 0.41)§ −0.39 (−1.30, 0.51)‖ −0.37 (−1.22, 0.48)¶ |
0.02 (−0.29, 0.33) | 0.03 (−0.28, 0.34)§ −0.02 (−0.32, 0.29)‖ −0.02 (−0.33, 0.30)¶ |
| Blood Pressure‡ | ||||
| Ideal Health (n=158) | Ref | Ref | Ref | Ref |
| Intermediate/Poor Health (=151) | −1.14 (−1.83, −0.45) | −0.96 (−1.62, −0.29)# | 0.02 (−0.19, 0.24) | 0.09 (−0.12, 0.31)# |
| Continuous variables | ||||
| BMI, kg/m2 (n=291) | 0.05 (−0.004, 0.11) | 0.06 (0.001, 0.11)§ | 0.01 (−0.01, 0.03) | 0.02 (−0.01, 0.04)§ |
| Total cholesterol, 10 mg/dL (n=275) | −0.07 (−0.18, 0.04) | −0.06 (−0.15, 0.04)§ −0.06 (−0.16, 0.04)‖ −0.05 (−0.14, 0.04)¶ |
0.01 (−0.02, 0.03) | 0.01 (−0.02, 0.04)§ 0.004 (−0.02, 0.03)‖ 0.005 (−0.02, 0.03)¶ |
| Systolic blood pressure, 10 mmHg (n=309) | −0.46 (−0.71, −0.21) | −0.39 (−0.63, −0.15)# | 0.004 (−0.06, 0.07) | 0.03 (−0.04, 0.10)# |
| Diastolic blood pressure, 10 mmHg (n=309) | −0.60 (−0.98, −0.22) | −0.52 (−0.89, −0.14)# | 0.01 (−0.09, 0.11) | 0.04 (−0.06, 0.15)# |
Body mass index: (1) poor health: ≥30 kg/m2; (2) intermediate health: 25-29.9 kg/m2; (3) ideal health: <25 kg/m2
Total cholesterol: (1) poor health: ≥240 mg/dL; (2) intermediate health: 200–239 mg/dL or treated to goal; (3) ideal health: <200 mg/Dl
Blood pressure: (1) poor health: Systolic ≥140 or Diastolic ≥90 mm Hg; (2) intermediate health: Systolic 120–139 or Diastolic 80–89 mm Hg or treated to goal; (3) ideal health: <120/<80 mm Hg
Adjusted for race (black vs. non-black) and prednisone use ever during pregnancy
Adjusted for race (black vs. non-black) and anti-malarial use ever during pregnancy
Adjusted for race (black vs. non-black), prednisone use ever during pregnancy, and anti-malarial use ever during pregnancy
Adjusted for race (black vs. non-black) and renal involvement during pregnancy (Renal LAI ≥1)