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Overview of proposed PD-1 & PD-L1/L2 intra-cellular signaling between T cells and/or macrophage/monocytes, among others (e.g. PMN, DC and/or EC/EpiCs, which may express PD-1 and/or PD-Ls). The activation pathway is indicated by a ‘thunder bolt’ symbol, while suppressive effects are denoted with a dashed line.
