Table 1.

Distance of genes with interaction-disrupting (Dis) and non-disrupting (Non-Dis) dnMis mutations to seven classes of known ASD-associated genes in a protein interactome network background. Number of genes in each class is indicated in parentheses. Genes carrying de novo protein truncating variants (dnPTVs) in SSC data were excluded from the analyses. P-values were calculated using one-tail U-test (P < 0.05 in bold).

	Proband					Sibling
	Dis (109)		Non-Dis (342)		P-value	Dis (68)		Non-Dis (241)		P-value
	Mean	SD	Mean	SD		Mean	SD	Mean	SD
FMRP (794)	2.61	0.38	2.85	0.46	1.5×10−6	2.77	0.37	2.77	0.48	0.57
CHM (408)	2.55	0.38	2.79	0.47	1.3×10−6	2.70	0.40	2.72	0.50	0.44
EMB (1,865)	2.65	0.38	2.88	0.46	2.9×10−6	2.79	0.38	2.81	0.48	0.45
PSD (1,395)	2.61	0.37	2.84	0.46	2.4×10−6	2.76	0.37	2.77	0.47	0.47
SFARI (881)	2.69	0.38	2.92	0.46	1.8×10−6	2.83	0.37	2.85	0.48	0.52
SFARI hq (141)	2.62	0.38	2.86	0.46	1.1×10−6	2.77	0.37	2.77	0.49	0.58
DN65 (65)	2.70	0.39	2.94	0.46	1.0×10−6	2.85	0.37	2.86	0.48	0.52