Table 1.

Semaglutide Significantly Lowered Plasma TG in LDLr^−/− Mice

	LDLr−/−					ApoE−/−
	Vehicle, WD (n = 20)	Semaglutide, 4 μg/kg (n = 21)	Semaglutide, 12 μg/kg (n = 23)	Semaglutide, 60 μg/kg (n = 21)	Vehicle, Chow (n = 9)	Vehicle, WD (n = 16)	Semaglutide, 4 μg/kg (n = 18)	Semaglutide, 12 μg/kg (n = 18)	Semaglutide, 60 μg/kg (n = 18)	Vehicle, Chow (n = 8)
T-chol (mM)	27.4 ± 2.8	23.3 ± 2.1	23.9 ± 2.1	19.9 ± 1.5	5.9 ± 0.3∗∗∗∗	25.1 ± 0.9	26.6 ± 1.3	30.9 ± 1.6	33.0 ± 1.3∗∗	8.5 ± 0.4∗∗∗∗
TG (mM)	6.8 ± 0.8	6.8 ± 0.6	7.1 ± 0.7	4.4 ± 0.4∗	1.4 ± 0.1∗∗∗∗	1.5 ± 0.1	1.2 ± 0.1	1.3 ± 0.1	1.2 ± 0.1	1.4 ± 0.2∗∗∗∗

T-chol = total cholesterol; TG = triglyceride; WD = Western diet.

p Values (comparison vs. Vehicle, WD):

^∗∗∗∗p < 0.00001.

^∗∗p = 0.0125.

^∗p = 0.0342. 1-way ANOVA, Dunnett’s post hoc test.