Table 1.
LDLr−/− |
ApoE−/− |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Vehicle, WD (n = 20) | Semaglutide, 4 μg/kg (n = 21) | Semaglutide, 12 μg/kg (n = 23) | Semaglutide, 60 μg/kg (n = 21) | Vehicle, Chow (n = 9) | Vehicle, WD (n = 16) | Semaglutide, 4 μg/kg (n = 18) | Semaglutide, 12 μg/kg (n = 18) | Semaglutide, 60 μg/kg (n = 18) | Vehicle, Chow (n = 8) | |
T-chol (mM) | 27.4 ± 2.8 | 23.3 ± 2.1 | 23.9 ± 2.1 | 19.9 ± 1.5 | 5.9 ± 0.3∗∗∗∗ | 25.1 ± 0.9 | 26.6 ± 1.3 | 30.9 ± 1.6 | 33.0 ± 1.3∗∗ | 8.5 ± 0.4∗∗∗∗ |
TG (mM) | 6.8 ± 0.8 | 6.8 ± 0.6 | 7.1 ± 0.7 | 4.4 ± 0.4∗ | 1.4 ± 0.1∗∗∗∗ | 1.5 ± 0.1 | 1.2 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.1 | 1.4 ± 0.2∗∗∗∗ |
T-chol = total cholesterol; TG = triglyceride; WD = Western diet.
p Values (comparison vs. Vehicle, WD):
p < 0.00001.
p = 0.0125.
p = 0.0342. 1-way ANOVA, Dunnett’s post hoc test.