Figure 2.

Manhattan plot for stage 1 analyses of risk of moderate-to-severe asthma

Data are for 5135 cases with moderate-to-severe asthma and 25 675 controls assessed for 33·8 million well-imputed variants. p values have had genomic control applied. Red data points are signals meeting criteria for follow-up in stage 2 (p<1 × 10⁻⁶) and the dotted line indicates genome-wide significance (p<5 × 10⁻⁸). Loci are labelled with the nearest gene for the 24 signals meeting genome-wide significance in the meta-analysis. Quantile-quantile plot for this analysis is in the appendix.