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. 2018 Nov 24;37(1):207–214. doi: 10.1007/s11419-018-0457-2

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Effects of CB₁ receptor antagonist on CBD-induced pentobarbital potentiation in mice. Mice were pretreated with 2 or 5 mg/kg SR141716A by i.v. injection 10 min before CBD administration (10 mg/kg, i.v.) and then administered pentobarbital at 40 mg/kg by i.p. injection. Sleeping time was expressed as the mean % of control (Veh + Veh + pentobarbital) sleeping time (n = 8). Control sleeping time was 35 ± 3 min. Significant difference from control group (**p < 0.01)