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. 2018 Jul 19;37(1):45–58. doi: 10.1007/s11419-018-0433-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Effects of a challenge dose of 5-MeO-DIPT (2.5 mg/kg) on extracellular levels of DA, 5-HT and GLU measured in adulthood (PND 90) in the frontal cortex (FCX) in rats treated with 5-MeO-DIPT (8 × 2.5 mg/kg) during adolescence. a–c show the time-courses, while d shows the total effects expressed as the AUC of the percent of each basal level. Values are the mean ± SEM [n = 4 animals for saline/saline and 6 animals per experimental group (saline/5-MeO-DIPT and 5-MeO-DIPT 8 × 2.5/5-MeO-DIPT)]. The time of drug injection is indicated with an arrow. *p < 0.001 vs. sal/sal group; ^p < 0.001 vs. sal/5-MeO-DIPT group (time-course: repeated measures ANOVA and Tukey’s post hoc test; total effect: one-way ANOVA and Tukey’s post hoc test)