Fig. 5. Effect of dunnione on caerulein-induced acute pancreatitis in NQO1^−/− mice.

a, b Pancreas injury in NQO1^−/− mice was estimated by hematoxylin and eosin staining and histologic damage scores. Cont, saline (0.9% NaCl)-treated control group; CAE, 50 µg/kg caerulein-only group; CAE + Dun 10, caerulein plus 10 mg/kg dunnione combined group; CAE + Dun 20, caerulein plus 20 mg/kg dunnione combined group; CAE + Dun 40, caerulein plus 40 mg/kg dunnione combined group; Dun, 40 mg/kg dunnione-only group. Scale bar: 200 μm. c The pancreas-to-bodyweight ratio and serum amylase/lipase levels were measured. Each value represents the mean ± SD (n = 5). *P < 0.05, NS not significant