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. 2018 Dec 18;10(1):2. doi: 10.1038/s41419-018-1258-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Lentivirus containing CUL1 knockdown (sh-CUL1) and vector control (sh-Ctrl) plasmids were used to infect MDA-MB-231 cells, respectively. b The migration and invasion of MDA-MB-231 cells with CUL1 knockdown and vector control. c The number of cell migration and invasion per field was counted in five random fields (n = 3/group). d The HUVECs cell proliferation absorbance (OD) value in the conditioned medium collected from MDA-MB-231 cells with CUL1 knockdown and vector control. e The tube formation by HUVECs in the conditioned medium collected from MDA-MB-231 cells with CUL1 knockdown and vector control. f The number of tubes formed per field was counted in five random fields (n = 3/group). Data were presented as mean ± SD, *P < 0.05, **P < 0.001 (Student’s t-test)