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. 2018 Dec 18;10(1):2. doi: 10.1038/s41419-018-1258-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a MDA-MB-231 cells were transiently transfected with CUL1 siRNA (si-CUL1) and vector siRNA control (si-Ctrl) in triplicate. b, c The heat map and volcano plot were used to indicate the significantly differential gene expressions in MDA-MB-231 cells with CUL1 knockdown and vector control. d The classification of disease and function was conducted to enrich the differential genes in the migration of cancer cells