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. 2018 Dec 18;10(1):4. doi: 10.1038/s41419-018-1207-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b After induced by estrogen for 12, 24, 48, 72, and 96 h in RL-952 cell lines, the expression of miR-200c in RL-952 and Ishikawa cell lines increased but HEC-1B and JEC cell lines was no significant change. c, d The RNA level of PTEN and PTENP1 was no significant change with RL-952 and Ishikawa cell lines after E2-induced for 48 h. g Western blot showed that the expression of PTEN protein in RL-952 cells was downregulated after E2-induced for 48 h. The results are presented as the mean of triplicate assays, with S.D. **P < 0.01