Fig. 6.

ROC curves of MMP-1, ADAM9, kallikrein 5, cathepsin V and their combination The saliva concentrations of MMP-1, ADAM9, kallikrein 5 and cathepsin V, which were detected by ELISA kit, were analyzed with ROC curves. a All of the four proteases and their combination; b ADAM9, kallikrein 5, cathepsin V and their combination (A9K5Cv); c MMP-1, kallikrein 5, cathepsinV and their combination (M1K5Cv); d MMP-1, ADAM9, cathepsin V and their combination (M1A9Cv); e MMP-1, ADAM9, kallikrein 5 and their combination (M1A9K5). Compared with the protease alone, all of the AUCs of combinations were significantly increased compared with those of proteases alone