Table 3.
Concentrations of saliva proteases detected by ELISA
| Analyte/control | Healthy | JBO fibroma | OSCC | CPD |
|---|---|---|---|---|
| (Mean OD) | (Mean OD) | (Mean OD) | (Mean OD) | |
| ADAM8 | 0 | 0.101 ± 0.001 | 0.486 ± 0.110a | 0.205 ± 0.03 |
| ADAM9 | 0 | 0 | 0.367 ± 0.05a | 0.11 ± 0.002 |
| ADAMTS1 | 0 | 0 | 0.177 ± 0.009a | 0.09 ± 0 |
| ADAMTS13 | 0 | 0 | 0.294 ± 0.025c | 0 |
| MMP-1 | 0 | 0 | 0.304 ± 0.103 | 0 |
| MMP-2 | 0 | 0 | 0.878 ± 0.315 | 0 |
| MMP-3 | 0 | 0 | 0.718 ± 0.209 | 0 |
| MMP-7 | 0 | 0 | 0.304 ± 0.115a | 0.115 ± 0.091 |
| MMP-8 | 0.835 ± 0.219 | 1.116 ± 0.306 | 0.978 ± 0.315 | 0.965 ± 0.298 |
| MMP-9 | 1.012 ± 0.303 | 0.584 ± 0.198 | 0.156 ± 0.09b | 0.538 ± 0.126 |
| MMP-10 | 0 | 0 | 0.969 ± 0.312 | 0 |
| MMP-12 | 0 | 0 | 0.365 ± 0.113a | 0.12 ± 0.08 |
| MMP-13 | 0 | 0 | 0.375 ± 0.105 | 0 |
| Cathepsin A | 0.456 ± 0.14 | 1.056 ± 0.320 | 0.697 ± 0.112 | 0.925 ± 0.325 |
| Cathepsin B | 0.462 ± 0.146 | 0.651 ± 0.151 | 0.262 ± 0.013b | 0.768 ± 0.252 |
| Cathepsin C | 0.365 ± 0.231 | 0.35 ± 0.156 | 0.358 ± 0.178 | 0.325 ± 0.163 |
| Cathepsin D | 1.112 ± 0.352 | 1.125 ± 0.165 | 0.421 ± 0.154b | 1.032 ± 0.257 |
| Cathepsin E | 0 | 0 | 0.103 ± 0.005c | 0 |
| Cathepsin L | 0 | 0 | 0 | 0 |
| Cathepsin S | 0.728 ± 0.215 | 0.556 ± 0.124 | 0.592 ± 0.165 | 0.517 ± 0.201 |
| Cathepsin V | 0.19 ± 0.06 | 0.101 ± 0.004 | 0.878 ± 0.169a | 0.05 ± 0.0 |
| Cathepsin X/Z/P | 0.628 ± 0.132 | 0.774 ± 0.268 | 0.312 ± 0.145b | 0.575 ± 0.208 |
| Kallikrein 3/PSA | 0 | 0 | 0 | 0 |
| Kallikrein 5 | 0.175 ± 0.112 | 0.272 ± 0.153 | 1.085 ± 0.312a | 0.348 ± 0.114 |
| Kallikrein 6 | 0.4 ± 0.105 | 0.472 ± 0.162 | 0.105 ± 0.05b | 0.565 ± 0.151 |
| Kallikrein 7 | 0 | 0 | 0.208 ± 0.101a | 0.105 ± 0.04 |
| Kallikrein 10 | 0.515 ± 0.231 | 0.547 ± 0.198 | 1.098 ± 0.305a | 0.638 ± 0.246 |
| Kallikrein 11 | 1.065 ± 0.289 | 0.985 ± 0.306 | 0.985 ± 0.268 | 0.745 ± 0.197 |
| Kallikrein 13 | 0.5 ± 0.106 | 0.486 ± 0.113 | 0.266 ± 0.098b | 0.698 ± 0.215 |
| DPPIV/CD26 | 1.201 ± 0.316 | 0.857 ± 0.215 | 1.123 ± 0.298 | 1.157 ± 0.302 |
| Neprilysin/CD10 | 0 | 0 | 0.394 ± 0.115 | 0.251 ± 0.108 |
| Proprotein convertase 9 | 0.165 ± 0.05 | 0.201 ± 0.08 | 0 | 0.058 ± 0 |
| Proteinase 3 | 0.415 ± 0.213 | 0.167 ± 0.09 | 0 | 0.383 ± 0.109 |
| uPA/Urokinase | 0 | 0 | 0.976 ± 0.296d | 0.258 ± 0.107 |
| Presenilin | 0 | 0 | 0 |
ADAM a disintegrin and metalloprotease, ADAMTS a disintegrin and metalloproteinase with thrombospondin motifs, MMP matrix metalloproteinases, uPA urokinase-type plasminogen activator
a,bP < 0.05 compared with healthy controls or patients with CPD or OBM
cOnly detected in OSCC saliva
dP < 0.05 compared with CPD