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. 2018 Dec 26;25(13):3661–3673.e3. doi: 10.1016/j.celrep.2018.11.098

Figure 7.

Figure 7

Extra Copy of azot Improves Long-Term Memory Formation in Flies Expressing Amyloid-β42

(A) Schematic depicting the courtship suppression assay to measure long-term memory.

(B) Graph showing the courtship index of sham males (gray bars) versus trained males (red bars) of the indicated genotypes. Statistical analysis was based on Student’s t test.

(C) Graph showing the memory index of the indicated genotypes. Statistical analysis was based on ANOVA.

(D) Amyloid-β42-induced neuronal death is mediated by fitness comparison encoded by flower and executed by azot. Removal of amyloid-β42-compromised neurons via cell competition has a strong net beneficial effect at the organismal level, protecting against motor decline, memory impairment, and premature death.

Error bars show SEM, and numbers within the bars indicate the number of individuals tested. ∗∗∗p < 0.001, ∗∗p < 0.01, ∗p < 0.05. See also Figure S6 and Videos S4, S5, S6, S7, and S8.