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. 2018 Dec 13;9:2550. doi: 10.3389/fimmu.2018.02550

Table 2.

The developed “humanized mouse model(s)” for asexual blood stage infection of P. falciparum.

P. falciparum strain(s) Humanized mice Applications References
NF54 or multiresistant T24 BXN (Beige/Xid/Nude) First rodent model for P.falciparum study, to test the novel compounds for the drug development and evaluation of drug responses, vaccine development (136138)
FUP, NF54, 3D7, Dd2 and clinical isolates SCID (Severe Combined Immunodeficiency) and NOD/SCID Helpful in in-vivo studies of human malaria parasites and vaccine development (139141)
Mouse-adapted 3D7 NOD/SCID/β2microglobulin (β2m)−/− in-vivo experimental drug/exposure-response assay (142)
Mouse-adapted 3D7 NOD/SCID/IL-2 receptor γ chain (IL2Rγ)nullor NSG mice To check the response against various antimalarial therapeutics (143, 144)
Different parasite strains (3D7,UPA and K1) without any prior adaptation NOD/SCID/IL-2 receptor γ chain (IL2Rγ)null or NSG mice with an additional treatment of clodronate delivered through liposomes Most comprehensive humanized mouse model allowing to develop the sexual stage parasites besides the asexual-blood stage development (134, 145)
NF54, 3D7 HLA-transgenic mice Discovery of novel protective malaria antigen and immune responses (146)
NF54 TK/NOG Used to assess the drug toxicology and metabolism, and P. falciparum infection in transplanted human hepatocytes (6)

TK/NOG, thymidine kinase/NOD/Shi-scid/IL-2Rγnull mice; HLA, human leukocytes antigen; 3D7, NF54, PAM, different P. falciparum strain.