Table 1.
Literature data of main features of isthmus vs. non isthmus thyroid cancer.
| Authors | Lee et al. (15) | Hahn et al. (16) | Karatzas et al. (17) | Goldforb et al. (18) | Lee et al. (6) | Song et al. (19) | Wang et al. (20) | Xiang et al. (21) |
|---|---|---|---|---|---|---|---|---|
| No. of patients | 190 | 2,623 (144 analyzed in the study) | 575 | 281 | 1,973 | 194 | 3,577 | 949 |
| Patients with isthmus DTC | 7.3% | 2.2% (48 analyzed in the study) | 9.3% | 4.2% | 9.2% | 45 | 2% | 7.3% |
| Surgical procedure in isthmus DTC vs. in non isthmus DTC | TT+CDN vs. TT+CDN | 81.3% TT+CND 18.7% TT+CND+LND vs. 85.4% TT+CND 14.6% TT+CND+LND | TT+CND*1 vs. TT+CND*1 | TT ± CND+LND*2 vs. – | 90.6% TT+CND ipsilateral 9.4% TT+CND+LND vs. 81.8% TT+CND ipsilateral 18.2% TT+CND+LND | 86.7% TT+CND 13.3% TT+ CND+ LND vs. 83.3% TT+CND 16.7% TT+CND+LND | TT+ CND vs. – | SubTT+CND+LND*2 vs. Loboisthmusectomy or TT+CND+LND*2 |
| Patients with multifocality in isthmus DTC vs. in non isthmus DTC | 64.3 vs. 40.3% | 54.2 vs. 45.8% | 51.9 vs. 35.7% | 67 vs. – | 48.6 vs. 39.8% | – | – | – |
| Patients with capsular invasion in isthmus DTC vs. in non isthmus DTC | – | – | 25.9 vs. 22.1% | 33 vs. – | 70.2 vs. 60.8% | 46.7 vs. 4.4% | – | – |
| Patients with ETE in isthmus DTC vs. in non isthmus DTC | 100 vs. 54% | 83.3 vs. 65.6% | – | – | – | – | 11% vs. – | – |
| Patients with CLN mts in isthmus DTC vs. in non isthmus DTC | 71.4 vs. 44.6% | 68.8 vs. 58.3% | 29.6 vs. 16.3% | 50% vs. – | 40.3 vs. 42.1% | 71.1 vs. 40.3% | 46.6% vs. – | 44 vs. 28.2% |
| Patients with LLN mts in isthmus vs. in non isthmus DTC | 14.3 vs. 11.9% | 16.7 vs. 14.6% | 8% vs. – | 9.4 vs. 18.2% | – | 4 vs. 4.6% |
DTC, differentiated thyroid cancer; TT, total thyroidectomy; ETE, extrathyroidal extension; CLN, central lymph nodes; LLN, lateral lymph nodes; CND, central lymph node dissection; LND, lateral lymph node dissection; mts, metastasis;
*1
if mts detected by FNA or palpation;
*2
if mts detected by US or FNA. Bold values correspond to patients with isthmus DTC.