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. 2018 Dec 12;5:311. doi: 10.3389/fvets.2018.00311

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Copyright © 2018 Taguchi, Koh, Takawira, Rademacher, Gilad, Aronson and Lopez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peak force (PF: upper panels) and impulse (Imp: lower panels) percent change (mean +/- SEM) in dogs with different radiographic coxofemoral joint osteoarthritis scores (CFJ OA score 1: left panels; score 2: central panels; score 3: right panels) following treatment with agmatine (black bars), placebo (white bars), or carprofen (gray bars). In each panel, Fz represents vertical force (left 3 bars), Fy(b) represents braking force (central 3 bars), and Fy(p) represents propulsion force (right 3 bars). Columns with different letters are significantly different among treatment groups for the indicated ground reaction force (p < 0.05). The dashed horizontal lines demarcate 5% positive (upper) or negative (lower) changes in each ground reaction force.