Figure 1.

A schematic representation of the cross-talk between APC, NK, and T cells with a potential influence of inflammasome regulating immune cell activity (A), and a summary of events involved in tumor growth and metastasis and a proposed mechanism to block inflammasome activity (B). IL-1β and IL-18 are well-known primary targets; however, multiple cytokines-chemokines could be simultaneously reduced in the tumor microenvironment with subsequent inhibition of immune suppressor cells, providing a space to enhance anti-tumor immunity. WFA: Withaferin-A.