Table 1.

Pro-tumor and anti-tumor activity of inflammasomes in various cancer types.

Inflammasome complex proteins	Pro-tumor activity with increased expression in cancer	Anti-tumor activity with increased expression in cancer
NLRP1	Melanoma, Breast cancer	Colorectal cancer
NLRP3	Breast cancer, Lung cancer, Gastric cancer, Melanoma, HNCC, OSCC, GBM, and colitis-associated cancer	Colorectal cancer, HCC
NLRC4	Gastric cancer, Breast cancer	Either anti-tumor or no effect in colitis-associated cancer
NLRP6	Breast cancer, Gastric cancer	Colitis-associated cancer
NLRP12	Prostate cancer, Gastric cancer	Colon cancer
AIM2	Acute pancreatitis, Breast cancer; Lung cancer; Prostatic diseases	Not known

HNCC, Head and neck cell cancer; OSCC, Oral squamous cell carcinoma; HCC, Hepatocellular carcinoma; GBM, Glioblastoma.