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. 2018 Dec 12;9:1461. doi: 10.3389/fphar.2018.01461

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Copyright © 2018 Li, Jiang, Wang, Lv, Xie, Yang, Guo, Tang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of warfarin on Chuanxiong (Senkyunolide I) pharmacokinetics in rats (the mean plasma ± SD concentration-time curves for senkyunolide I, n = 8). (A) CO group compares to CN group; (B) WCN group compares to CN group; (C) WCO group compares to CO group; (D) WCO group compares to WCN group. Warfarin and biliary drainage both increase the bioavailability of Chuanxiong (Senkyunolide I) in rats. CN, healthy rats after a single administration of Chuanxiong; CO, rats with biliary drainage after a single administration of Chuanxiong; WCN, healthy rats after the administration of warfarin and Chuanxiong; WCO, rats with biliary drainage after the administration of warfarin and Chuanxiong.