Table 2.
Concurrent autoimmune diseases among cases and controls as well as first-degree relatives.
| Concurrent autoimmune diseases | Cases with condition (n=306), n (%) | Controls with condition (n=1162), n (%) | P value | Cases with an FDRa condition (n=306), n (%) | Controls with an FDR condition (n=1162), n (%) | P value |
| Any extrahepatic autoimmune disease | 128 (41.83) | 218 (18.76) | <.001 | 171 (55.88) | 415 (35.71) | .001 |
| Autoimmune hepatitis | 306 (100.00) | 0 (0.00) | NSb | 14 (4.58) | 26 (2.24) | NS |
| Autoimmune thyroid disease | 49 (16.01) | 67 (5.77) | <.001 | 61 (19.93) | 89 (7.66) | .001 |
| Celiac disease | 16 (5.23) | 15 (1.29) | <.001 | 19 (6.21) | 33 (2.84) | .007 |
| Crohn disease | 7 (2.28) | 13 (1.11) | NS | 9 (2.94) | 41 (3.53) | NS |
| Ulcerative colitis | 12 (3.92) | 12 (1.00) | <.001 | 25 (8.17) | 46 (4.00) | .004 |
| Lupus | 14 (4.58) | 14 (1.20) | <.001 | 15 (4.90) | 33 (2.84) | NS |
| Multiple sclerosis | 1 (0.33) | 7 (0.60) | .008 | 8 (2.61) | 33 (2.84) | NS |
| Primary sclerosing cholangitis | 12 (3.92) | 100 (0.86) | <.001 | 1 (0.31) | 0 (0.00) | .001 |
| Primary biliary cholangitis | 50 (16.34) | 80 (0.69) | <.001 | 5 (1.63) | 13 (1.12) | NS |
| Psoriasis | 22 (7.19) | 60 (5.16) | .02 | 48 (15.69) | 109 (9.38) | .002 |
| Raynaud phenomenon | 23 (7.52) | 21 (1.81) | <.001 | 58 (18.95) | 119 (10.24) | .001 |
| Rheumatoid arthritis | 19 (6.21) | 46 (4.00) | <.001 | 56 (18.30) | 177 (15.23) | NS |
| Scleroderma | 3 (1.00) | 30 (0.26) | .003 | 2 (0.65) | 10 (0.86) | NS |
| Sjögren syndrome | 27 (8.82) | 50 (0.43) | <.001 | 30 (4.25) | 53 (0.77) | .001 |
| Type 1 diabetes mellitus | 3 (1.00) | 22 (1.89) | NS | 30 (9.80) | 53 (4.56) | .001 |
aFDR: first-degree relative.
bNS: not significant.