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. 2018 Oct 1;38(1):e100615. doi: 10.15252/embj.2018100615

Figure 1. αKG effects on PGC competency and primordial germ cell development.

Figure 1

(A) A transition from naïve mESCs to primed EpiLCs coincides with reduced OXPHOS and increased glycolysis that reverses when EpiLCs convert to PGCLCs. (B,C) Addition of αKG prolongs PGC competency from 48 to 72 h, potentially by locking‐in an epigenetic pattern regulated by KDM3a/b and TET1 enzyme activities. mESC, mouse embryonic stem cells; EpiLCs, epiblast‐like cells; PGCLCs, primordial germ cell‐like cells; PGC, primordial germ cell; αKG, alpha‐ketoglutarate.