Figure 1.

Logic gate design strategy based on light-up RNA aptamers. (A) malachite green (MG)-binding RNA aptamer used to design four simple AND, OR, NAND, and NOR logic gates. (B) Illustration of RNA half adder system based on MG RNA and Broccoli RNA aptamers conjugated with RNA tetragonal nanoparticle. Fluorophores MG and DFHBI in their unbound state exhibit low fluorescence (0), the emission of these chromophores increases upon binding to their corresponding RNA aptamers (1).