Table 1.
High-resolution mass spectrometry (HR-MS) analyses of human plasma 28 carbon very-long-chain dicarboxylic acids (VLCDCAs). The molecular anions of endogenous VLCDCAs were monitored in organic extracts of 0.1 mL of human plasma. R, ratio of the peak area of the endogenous VLCDCA to the peak area of 1 nanomole of the internal standard [2H28]dicarboxylic acid (DCA)16:0.
| VLCDCA | Molecular Formula | Published Nomenclature [17,18,19,20,21,22] | Exact Mass | [M − H]− | R | ppm Mass Error |
|---|---|---|---|---|---|---|
| [2H28] DCA 16:0 | Internal std. | 314.39016 | 313.3829 | 1.60 | ||
| 28:0 | C28H54O4 | 454.4022 | 453.3949 | 0.067 | 1.56 | |
| 28:1 | C28H52O4 | GTA-452 | 452.3866 | 451.3793 | 0.276 | 1.30 |
| 28:2 | C28H50O4 | GTA-450 | 450.3709 | 449.3636 | 0.773 | 1.73 |
| 28:3 | C28H48O4 | GTA-448 | 448.3553 | 447.3480 | 1.084 | 1.24 |
| 28:4 | C28H46O4 | GTA-446 | 446.3396 | 445.3323 | 0.778 | 1.18 |
| 28:5 | C28H44O4 | 444.3240 | 443.3167 | 0.047 | 0.22 |