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. 2018 Dec 17;10(12):720. doi: 10.3390/v10120720

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Features of the predicted HDAg protein. Alignment of the amino acid sequences (small delta antigen) translated from the genomes of HDV and the avian HDV delta-like agent. The potential coiled-coil region is highlighted, including the presence of leucine residues in the correct spacing for a leucine zipper (filled red circle). The delta antigen does not have a strict requirement for leucine in the d-position of the heptad repeat. Additional leucine residues are shown by circles in light red. Serine residues that are conserved between different HDV genotypes and post-translationally modified (phosphorylated) are highlighted with an asterisk. The conserved arginine and lysine residues modified by methylation (Arg-Me) and acetylation (Lys-Ac) are indicated. NLS: Nuclear localisation signal.