Figure 4.

The relationship of plasma osmolality to plasma AVP (panel A), and the relationship of plasma AVP to urine osmolality (panel B). Reprinted with copyright from Robertson et al. [71]. Plasma was collected during recumbent rest in three states of water balance: ad libitum fluid intake, following an acute water load (20 ml/kg), and after acute periods of fluid restriction. The data represent healthy adults and patients with diverse types of polyuria (i.e., abnormally large urine volume and frequency). Dashed lines represent the sensitivity limit of the plasma AVP assay.