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. 2018 Dec 1;10(12):1846. doi: 10.3390/nu10121846

Figure 1.

Figure 1

Diet-induced metabolic disease (DIMD) mice were fed an HFD and treated with Rubus occidentalis (RO) or drugs (atorvastatin or metformin) for 16 weeks. The changes in the fasting blood glucose (A) of the animals were observed every two weeks and the values from the final week are shown in (B). Mice glucose tolerance was analyzed by intraperitoneal glucose tolerance testing (IPGTT) (C). RD: regular diet, HFD: high-fat diet, HFD + RO 125: HFD-fed mice treated with a low dose (125 mg/(kg·day)) of aqueous extract of RO, HFD + RO 250: HFD-fed mice treated with a high dose (250 mg/(kg·day)) of RO. HFD + Atorva: HFD-fed mice treated with atorvastatin (10 mg/(kg·day)). HFD + Met: HFD-fed mice treated with metformin (250 mg/(kg·day)). Values are presented as mean ± standard error of mean (SEM) (n = 7, each group). * p < 0.05, ** p < 0.01, and *** p < 0.001 compared with RD mice. † p < 0.05, † † p < 0.01, and † † † p < 0.001 compared with HFD mice.