Figure 2.

DIMD mice were fed an HFD with RO or drugs (atorvastatin or metformin) for 16 weeks. Serum from each mouse and the supernatant of their homogenized hepatic tissue solutions were prepared. Total cholesterol (T-CHO) (A) and triglyceride (TG) (B) levels in the serum as well as TG levels in the liver (C) were measured using a biochemistry analyzer. Mice were grouped as indicated in Figure 1. Values are presented as means ± SEM (n = 7, each group). * p < 0.05, ** p < 0.01, and *** p < 0.001 compared with RD mice. ^† p < 0.05, ^{† †} p < 0.01, and ^{† † †} p < 0.001 compared with HFD mice.