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. 2018 Nov 30;10(12):678. doi: 10.3390/v10120678

Figure 2.

Figure 2

SYL1712 inhibits EBOV infection at late entry step. Pseudotyped HIV-1/EBOV was incubated with A549 cells at 4 °C at the one-hour time point. After one hour of incubation, the pseudovirus was removed and temperature was shifted to 37 °C to trigger virus internalization. SYL1712 (10 µM) and benztropine (25 µM) were introduced at different time points of virus infection, and the compounds’ effects on viral infection are shown (means ± SD; n = 3). The luciferase signals were normalized based on the signals from the vehicle DMSO-treated wells at each time point. Relative luciferase signal at 100% means the drug has no effect on the EBOV entry at each time point.