Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 30;10(12):678. doi: 10.3390/v10120678

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Structure activity relationship (SAR) of diarylquinoline compounds against EBOV (A) Summary of the SAR analysis the diarylquinoline compounds as Ebola virus entry inhibitors. (B,C) Predicted binding mode of SYL1712 with Ebola glycoprotein by molecular docking (PDB code: 5JQ7). (B) Superposition of SYL1712 (cyan) with toremifene (pink) shows similar binding orientations at the interface between GP1 and GP2; (C) SYL1712 (cyan) forms both hydrophobic interactions (V66, Y517, L558, L184 and L186) and electrostatic interactions (D522) with EBOV GP (C).