Table 1.
Significant lipid markers of coffee consumption *.
| Lipid Class † | Lipid Species | Group Effect | Fold of Change § | |||
|---|---|---|---|---|---|---|
| p-Value | q-Value | 4 Cups/0 Cup | 8 Cups/0 Cup | 8 Cups/4 Cups | ||
| CE | CE(20:4) | 0.0296 | 0.4529 | 0.9 | 0.92 | 1.02 |
| FFA | FFA(20:3) | 0.0021 | 0.297 | 0.9 | 0.87 | 0.96 |
| FFA(20:4) | 0.0012 | 0.2492 | 0.95 | 0.87 | 0.91 | |
| FFA(22:2) | 0.0481 | 0.4529 | 0.95 | 0.89 | 0.94 | |
| FFA(22:6) | 0.0415 | 0.4529 | 0.98 | 0.89 | 0.91 | |
| TAG | TAG47:1-FA17:0 | 0.0483 | 0.4529 | 1.26 | 1.4 | 1.11 |
| TAG51:3-FA15:0 | 0.0401 | 0.4529 | 0.82 | 0.91 | 1.11 | |
| TAG52:4-FA16:1 | 0.0317 | 0.4529 | 0.8 | 0.92 | 1.15 | |
| TAG52:5-FA16:1 | 0.0329 | 0.4529 | 0.77 | 0.89 | 1.16 | |
| TAG52:5-FA20:5 | 0.05 | 0.4529 | 1.07 | 1.25 | 1.18 | |
| TAG52:6-FA16:1 | 0.041 | 0.4529 | 0.78 | 0.9 | 1.14 | |
| TAG53:3-FA16:0 | 0.0211 | 0.4529 | 0.88 | 0.87 | 1 | |
| TAG53:3-FA18:1 | 0.0242 | 0.4529 | 0.9 | 0.93 | 1.03 | |
| TAG53:4-FA16:0 | 0.0229 | 0.4529 | 0.84 | 0.89 | 1.07 | |
| TAG53:4-FA18:2 | 0.0289 | 0.4529 | 0.82 | 0.88 | 1.08 | |
| TAG53:5-FA18:3 | 0.048 | 0.4529 | 0.87 | 0.92 | 1.06 | |
| TAG54:3-FA18:1 | 0.0354 | 0.4529 | 0.82 | 0.9 | 1.09 | |
| TAG54:3-FA20:1 | 0.0368 | 0.4529 | 0.84 | 0.94 | 1.13 | |
| TAG54:4-FA20:1 | 0.0306 | 0.4529 | 0.82 | 0.94 | 1.14 | |
| TAG55:3-FA18:1 | 0.0353 | 0.4529 | 0.82 | 0.86 | 1.05 | |
| TAG55:4-FA18:1 | 0.0198 | 0.4529 | 0.82 | 0.85 | 1.04 | |
| TAG55:5-FA18:1 | 0.0208 | 0.4529 | 0.77 | 0.83 | 1.08 | |
| TAG56:3-FA18:1 | 0.0103 | 0.4529 | 0.81 | 0.87 | 1.07 | |
| TAG56:3-FA20:1 | 0.0155 | 0.4529 | 0.79 | 0.86 | 1.09 | |
| TAG56:4-FA18:1 | 0.0124 | 0.4529 | 0.8 | 0.87 | 1.08 | |
| TAG56:4-FA20:1 | 0.0314 | 0.4529 | 0.71 | 0.81 | 1.14 | |
| TAG56:4-FA20:2 | 0.0141 | 0.4529 | 0.84 | 0.88 | 1.05 | |
| TAG56:5-FA18:1 | 0.0221 | 0.4529 | 0.83 | 0.9 | 1.09 | |
| TAG56:5-FA20:2 | 0.0051 | 0.4529 | 0.77 | 0.84 | 1.08 | |
| TAG56:5-FA20:3 | 0.0215 | 0.4529 | 0.83 | 0.89 | 1.08 | |
| TAG56:5-FA20:4 | 0.0447 | 0.4529 | 0.84 | 0.91 | 1.07 | |
| TAG56:6-FA18:2 | 0.0132 | 0.4529 | 0.77 | 0.88 | 1.13 | |
| TAG56:6-FA20:2 | 0.0206 | 0.4529 | 0.76 | 0.84 | 1.11 | |
| TAG56:6-FA20:3 | 0.0077 | 0.4529 | 0.77 | 0.85 | 1.1 | |
| TAG56:6-FA20:4 | 0.0306 | 0.4529 | 0.81 | 0.88 | 1.08 | |
| TAG56:7-FA18:2 | 0.0457 | 0.4529 | 0.8 | 0.91 | 1.14 | |
| TAG56:7-FA20:3 | 0.042 | 0.4529 | 0.79 | 0.85 | 1.07 | |
| TAG56:7-FA22:4 | 0.0484 | 0.4529 | 0.87 | 0.92 | 1.06 | |
| TAG56:7-FA22:5 | 0.0384 | 0.4529 | 0.85 | 0.95 | 1.12 | |
| TAG56:9-FA20:4 | 0.0458 | 0.4529 | 0.83 | 0.92 | 1.11 | |
| TAG56:9-FA22:6 | 0.0229 | 0.4529 | 0.85 | 0.92 | 1.08 | |
| TAG57:8-FA22:6 | 0.0093 | 0.4529 | 0.87 | 0.91 | 1.04 | |
| TAG58:10-FA20:5 | 0.0161 | 0.4529 | 0.86 | 0.94 | 1.09 | |
| TAG58:10-FA22:5 | 0.0391 | 0.4529 | 0.74 | 0.84 | 1.14 | |
| TAG58:10-FA22:6 | 0.0388 | 0.4529 | 0.72 | 0.8 | 1.11 | |
| TAG58:7-FA22:4 | 0.0294 | 0.4529 | 0.81 | 0.89 | 1.11 | |
| TAG58:7-FA22:5 | 0.0109 | 0.4529 | 0.79 | 0.85 | 1.07 | |
| TAG58:8-FA20:4 | 0.0324 | 0.4529 | 0.85 | 0.9 | 1.06 | |
| TAG58:8-FA22:5 | 0.0386 | 0.4529 | 0.79 | 0.85 | 1.08 | |
| TAG58:9-FA22:5 | 0.0478 | 0.4529 | 0.78 | 0.86 | 1.1 | |
| TAG60:10-FA22:5 | 0.0349 | 0.4529 | 0.85 | 0.9 | 1.06 | |
| TAG60:10-FA22:6 | 0.0357 | 0.4529 | 0.82 | 0.92 | 1.13 | |
| TAG60:11-FA22:5 | 0.0038 | 0.4529 | 0.8 | 0.92 | 1.16 | |
| LPC | LPC(15:0) | 0.0142 | 0.4529 | 0.95 | 0.92 | 0.97 |
| LPC(17:0) | 0.0017 | 0.2886 | 0.96 | 0.9 | 0.93 | |
| LPC(18:1) | 0.0423 | 0.4529 | 0.98 | 0.93 | 0.95 | |
| LPC(20:2) | 0.0094 | 0.4529 | 0.95 | 0.89 | 0.93 | |
| LPC(20:3) | 0.0362 | 0.4529 | 0.94 | 0.91 | 0.96 | |
| LPC(20:4) | <0.0001 | 0.0088 | 0.94 | 0.87 | 0.93 | |
| LPC(22:1) | <0.0001 | 0.0313 | 0.91 | 0.78 | 0.86 | |
| LPC(22:2) | <0.0001 | 0.0051 | 0.94 | 0.79 | 0.84 | |
| PC | PC(17:0/20:4) | 0.0183 | 0.4529 | 0.91 | 0.91 | 1 |
| PC(18:0/16:1) | 0.0274 | 0.4529 | 1.09 | 1.3 | 1.19 | |
| PC(18:0/18:3) | 0.0375 | 0.4529 | 1.13 | 1.24 | 1.1 | |
| PC(18:0/20:2) | 0.0143 | 0.4529 | 1 | 1.11 | 1.11 | |
| PC(18:0/20:3) | 0.0361 | 0.4529 | 0.96 | 1.08 | 1.12 | |
| PC(18:1/20:4) | 0.0152 | 0.4529 | 0.92 | 0.91 | 0.99 | |
| PE | PE(18:0/20:1) | 0.0203 | 0.4529 | 0.97 | 1.12 | 1.16 |
| PE(O-16:0/18:2) | 0.0301 | 0.4529 | 1.08 | 1.19 | 1.11 | |
| PE(O-18:0/20:3) | 0.0458 | 0.4529 | 0.98 | 1.12 | 1.15 | |
| PE(P-16:0/18:2) | 0.0246 | 0.4529 | 1.07 | 1.18 | 1.1 | |
| PE(P-16:0/22:4) | 0.025 | 0.4529 | 0.89 | 1.01 | 1.14 | |
| PE(P-18:0/18:2) | 0.0406 | 0.4529 | 1.04 | 1.15 | 1.1 | |
| DCER | DCER(24:0) | 0.0475 | 0.4529 | 1 | 1.1 | 1.1 |
| LCER | LCER(26:1) | 0.0097 | 0.4529 | 0.95 | 1.08 | 1.13 |
CE: cholesteryl ester; FFA: free fatty acid; TAG: triacylglycerol; LPC: lysophosphatidylcholine; PC: phosphatidylcholine; PE: phosphatidylethanolamine; DCER: dihydroceramide; LCER: lactosylceramide. * Shown are results from RMA that meet nominal significance (p < 0.05, column 3). Bold-faced lipid species meet significance threshold of p < 0.05 (column 3) and q < 0.05 (column 4). † neutral lipids: CE, FFA, TAG; phospholipids: LPC, PC, PE; sphingolipids: DCER, LCER. § ANOVA contrasts: lipid levels that increase in response to coffee are shaded red (p < 0.05) or pink (0.05 < p < 0.10) and lipid levels that decrease are colored green (p < 0.05) or light green (0.05 < p < 0.10).