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. 2018 Nov 8;8(4):140. doi: 10.3390/biom8040140

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Intrinsically disordered protein (IDP) vs. structured protein. (LEFT) A diagram representing free SNAP-25 (synaptosome-associated protein of 25 kDa, green), which is disordered in isolation. The gray lines represent potential alternative conformations of the protein, consistent with a flexible structure. SNAP-25 folds into a stable structure upon binding its partner SNARE (soluble N-ethyl maleimide sensitive factor attachment receptor) proteins. (RIGHT) The SNARE complex [protein databank (PDB) ID: 1SFC)] with synaptobrevin-II (blue), syntaxin-1A (red), and SNAP-25 (green). Note SNAP-25 becomes stably structured within the SNARE complex.